Endocrine Abstracts

Introduction: Besides an incidental finding on MRI, headache, cranial nerve palsy, or pituitary insufficiency may lead to the diagnosis of a clivus tumor. Hormone secreting pituitary adenomas mimicking a clivus tumor can be easily identified by hormone testing, however, have to be considered prior to surgical procedures.Methods: Within the last 3 years, 9 patients were transferred to us with the diagnosis of a clivus tumor for surgical therapy.<p cla...

Objective: Postoperative nausea and vomiting is common after general anaesthesia and is reported by ~20–25% of all patients. The standard prophylaxis at the authors department is a single treatment of 4 mg of dexamethasone before initiating anesthesia. Dexamethasone is known to suppress ACTH and cortisol levels. The objective was to find out whether the standard PONV-prophylaxis of 4 mg of dexamethasone has an effect on postoperative levels of cortisol in patients undergo...

Objective: Cushing’s disease (CD) may cause atrophy of different regions of the human brain, mostly affecting the hippocampus and the cerebellum. This study evaluates the use of 3-T MRI of newly diagnosed patients with CD to detect atrophic degeneration with voxel-based volumetry.Methods: Subjects with newly diagnosed, untreated CD were included and underwent 3-T MRI. Images were analyzed using a voxelwise statistical test to detect reduction of bra...

Objectives: TSH-producing pituitary adenomas account for 1–2% of all pituitary tumors and there is debate wether transsphenoidal surgery or medical treatment should be recommended as first-line treatment. This study summarizes the authors surgical experience and puts it into context of literature concerning non-surgical treatment of TSHomas.Methods: A retrospective analysis of 12 patients including imaging, laboratory testing, short-term and long-te...

Transsphenoidal surgery is the treatment of choice for acromegaly. Cure is defined by normalization of age-related IGF1 and sufficient suppression of GH in the oral glucose tolerance test (OGTT). We investigated, if early postoperative hormone testing gives reliable information whether complete resection of a tumor was achieved and compared these findings with further follow-up data.So far, 22 patients underwent OGTT within a week after surgery, starting...

The Hippo kinase cascade is a crucial signalling pathway regulating organ growth during development in numerous organs. There is mounting evidence implicating this signalling pathway in tumour formation, where it is emerging as an anti-cancer target due to effective pharmacological inhibition of its transcriptional activators YAP/TAZ. We previously demonstrated activity of the Hippo kinase cascade in the mouse pituitary and nuclear association of YAP/TAZ with SOX2 expressing p...

Background: Adamantinomatous craniopharyngiomas (CP) are rare malformational tumors. The association between age at diagnosis and the outcome, clinical presentation and treatment of pediatric CP patients is not clear. The aim of this cohort study was to determine clinical presentation, outcome and quality of life in CP patients diagnosed at different AaD. Methods: Seven hundred and twenty-two patients diagnosed with CP were recruited 1999-2021 in HIT-End...

Introduction and Objective: Adult craniopharyngioma as a rare neoplasm of the central nervous system is still very poorly understood. The clinical implications for affected patients are numerous, ranging from endocrine dysfunction to visual loss and neurological impairment. Although the progress of this tumor entity is slow by nature, affected patients often suffer from multiple symptoms even after successful treatment with a strong impact on their individual quality of life. ...

Recently, somatic, heterozygous mutations in the gene encoding the deubiquitinase USP8 have been identified in 30–60% of corticotroph tumors. These mutations were found to hinder binding of 14-3-3 proteins, increasing its deubiquitinating activity. One substrate is Epidermal Growth Factor Receptor (EGFR), USP8 triggering EGFR recycling and increased EGFR signaling. However, tumors harboring mutations in USP8 are smaller than WT tumors, raising the debate if EGFR, as a pot...

Recently, somatic, heterozygous mutations in the gene encoding the deubiquitinase USP8 have been identified in 30–60% of corticotroph tumors. These mutations were found to hinder binding of 14-3-3 proteins, increasing its deubiquitinating activity. One substrate is Epidermal Growth Factor Receptor (EGFR), USP8 triggers EGFR recycling and increased EGFR signaling. However, tumors harboring mutations in USP8 are smaller than WT tumors, raising the debate if EGFR, as a poten...